Metgyl Tablet Use In Pregnancy & Lactation

Pregnancy/Reproduction: Studies in rats have not shown that metronidazole cause impaired fertility or birth defect in the foetus. Metronidazole, administered intraperitoneally to pregnant mice, has been shown to cause foeto-toxicity. When administered orally, no foetotoxicity was seen in pregnant mice. However, the use of metronidazole in the treatment of trichomoniasis is not recommended during the first trimester. Also, the 1-day course of therapy should not be used since this results in higher maternal and foetal serum concentrations.
Breast-feeding: Use is not recommended in nursing mothers since some studies in rats and mice have shown that metronidazole is carcinogenic and may cause adverse effects in the infant. However, use in the treatment of anaerobic bacterial infections or a short course of treatment with metronidazole for amoebiasis, severe periodontal infections, or trichomoniasis may be necessary in nursing mothers. During treatment with metronidazole, the breast milk should be expressed and discarded. Breast-feeding may be resumed 24 to 48 hours after treatment is completed.